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anti cd122 il 15rβ antibody  (Bio X Cell)


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    Bio X Cell anti cd122 il 15rβ antibody
    a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies <t>(α-CD122).</t> n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.
    Anti Cd122 Il 15rβ Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 96/100, based on 204 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+cd122+il+15r%CE%B2+antibody/Anti-Proximal+Nephrogenic+Antigen+(Renal+Cell+Marker)+Monoclonal+Antibody/pmc12686067-72-21-37
    Average 96 stars, based on 204 article reviews
    anti cd122 il 15rβ antibody - by Bioz Stars, 2026-10
    96/100 stars

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    1) Product Images from "Discovery of intrahepatic CD103 + cDC1/CD8 + T RM protective immune axis against acetaminophen-induced acute liver injury"

    Article Title: Discovery of intrahepatic CD103 + cDC1/CD8 + T RM protective immune axis against acetaminophen-induced acute liver injury

    Journal: Experimental & Molecular Medicine

    doi: 10.1038/s12276-025-01565-3

    a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies (α-CD122). n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies (α-CD122). n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Techniques Used: Blocking Assay, Cell Culture, Two Tailed Test

    a Based on the public single-cell RNA sequencing dataset from liver tissues of healthy donors and patients with APAP-ALI ( GSE223581 ), the relative expression levels of IL-15 were assessed between APAP patients and healthy donors, and the correlation between IL-15 level and CD69 + T RM population among the CD8 + T cells was evaluated. b Using the same dataset, the frequency of CD14⁺ monocytes among total liver immune cells (left) and the populaton of FCGR3A⁺ inflammatory monocytes among the CD14 + monocytes in the liver (right) were assessed between healthy donors and patients with APAP-ALI. For inflammatory monocytes, the ratio of FCGR3A >0.1 was assessed in the CD14 >0.1 population of monocytes. c The mRNA levels of IL-15 / IL-15RA were assessed by quantitative real-time PCR in LPS-activated hepatic DC1s isolated from noncancerous healthy tissues of resected liver specimens obtained from patients with HCC and other liver diseases. n = 3 per group. d , e The frequency of human hepatic CD8 + T RM cells when hepatic CD8 + T cells were cocultured with LPS-treated hepatic DC1s ( d ), in the presence of IL-15 blocking antibodies (α-CD122) ( e ). f The human hepatic inflammatory monocytes were cocultured with human hepatic T RM cells at a different ratio, and the frequency of annexin V + monocytes was assessed. n = 4 per group. Unpaired two-tailed Student’s t -test in a and b , multiple unpaired t -test in c and ordinary one-way ANOVA with Dunnett for the posttest f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05.
    Figure Legend Snippet: a Based on the public single-cell RNA sequencing dataset from liver tissues of healthy donors and patients with APAP-ALI ( GSE223581 ), the relative expression levels of IL-15 were assessed between APAP patients and healthy donors, and the correlation between IL-15 level and CD69 + T RM population among the CD8 + T cells was evaluated. b Using the same dataset, the frequency of CD14⁺ monocytes among total liver immune cells (left) and the populaton of FCGR3A⁺ inflammatory monocytes among the CD14 + monocytes in the liver (right) were assessed between healthy donors and patients with APAP-ALI. For inflammatory monocytes, the ratio of FCGR3A >0.1 was assessed in the CD14 >0.1 population of monocytes. c The mRNA levels of IL-15 / IL-15RA were assessed by quantitative real-time PCR in LPS-activated hepatic DC1s isolated from noncancerous healthy tissues of resected liver specimens obtained from patients with HCC and other liver diseases. n = 3 per group. d , e The frequency of human hepatic CD8 + T RM cells when hepatic CD8 + T cells were cocultured with LPS-treated hepatic DC1s ( d ), in the presence of IL-15 blocking antibodies (α-CD122) ( e ). f The human hepatic inflammatory monocytes were cocultured with human hepatic T RM cells at a different ratio, and the frequency of annexin V + monocytes was assessed. n = 4 per group. Unpaired two-tailed Student’s t -test in a and b , multiple unpaired t -test in c and ordinary one-way ANOVA with Dunnett for the posttest f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05.

    Techniques Used: RNA Sequencing, Expressing, Real-time Polymerase Chain Reaction, Isolation, Blocking Assay, Two Tailed Test

    Related Articles

    Injection:

    Article Title: Discovery of intrahepatic CD103 + cDC1/CD8 + T RM protective immune axis against acetaminophen-induced acute liver injury
    Article Snippet: .. For IL-12, IL-15, IL-18 and CCL2 neutralizing, mice were i.p. injected with 200 μg per mouse of anti-IL-12 antibody (clone R1-5D9), anti-CD122 (IL-15Rβ) antibody (clone TM-Beta1), anti-IL-18 antibody (clone YIGIF74-1G7) and anti-CCL2 antibody (clone 2H5) (all from BioXCell). ..



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    a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies <t>(α-CD122).</t> n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.
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    a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies <t>(α-CD122).</t> n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.
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    a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies (α-CD122). n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Experimental & Molecular Medicine

    Article Title: Discovery of intrahepatic CD103 + cDC1/CD8 + T RM protective immune axis against acetaminophen-induced acute liver injury

    doi: 10.1038/s12276-025-01565-3

    Figure Lengend Snippet: a , b The frequency of hepatic CD69 + T RM cells in WT APAP mice ( n = 3 per group per time point) ( a ) and in WT and Batf3-KO mice 24 h after APAP administration ( n = 3 per group) ( b ). c The frequency of Ki67 + cells in hepatic CD69 + KLRG1 − CD44 + CD8 + T RM cells in APAP mice. n = 4 per group. d The population of adoptively transferred OT-I T cells and of OT-I T RM cells in the liver of recipient mice after APAP administration. n = 3 per group. e The frequency of CD69 + T RM cells was assessed when APAP mice were pretreated with blocking antibodies against IL-12, IL-15 and IL-18. n = 4 per group. f The ALT level was assessed in APAP mice pretreated with IL-15 blocking antibodies (α-CD122). n = 3 per group per time point. g The frequency of IL-15Rα + cells in the hepatic DC1s and DC2s of APAP mice. n = 3 per group. h The frequency of T RM cells in hepatic CD8 + T cells when CD8 + T cells were cultured in the presence of IL-15. n = 4 per group. i The frequency of T RM cells among CD8 + T cells when hepatic CD8 + T cells were cocultured with LPS-stimulated hepatic DC1s of APAP mice in the presence of IL-15 blocking antibodies. n = 4 per group. Ordinary one-way ANOVA with Dunnett for posttest in a and e , unpaired two-tailed Student’s t -test in b – d and g – i and two-way ANOVA with Bonferroni for posttest in f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: For IL-12, IL-15, IL-18 and CCL2 neutralizing, mice were i.p. injected with 200 μg per mouse of anti-IL-12 antibody (clone R1-5D9), anti-CD122 (IL-15Rβ) antibody (clone TM-Beta1), anti-IL-18 antibody (clone YIGIF74-1G7) and anti-CCL2 antibody (clone 2H5) (all from BioXCell).

    Techniques: Blocking Assay, Cell Culture, Two Tailed Test

    a Based on the public single-cell RNA sequencing dataset from liver tissues of healthy donors and patients with APAP-ALI ( GSE223581 ), the relative expression levels of IL-15 were assessed between APAP patients and healthy donors, and the correlation between IL-15 level and CD69 + T RM population among the CD8 + T cells was evaluated. b Using the same dataset, the frequency of CD14⁺ monocytes among total liver immune cells (left) and the populaton of FCGR3A⁺ inflammatory monocytes among the CD14 + monocytes in the liver (right) were assessed between healthy donors and patients with APAP-ALI. For inflammatory monocytes, the ratio of FCGR3A >0.1 was assessed in the CD14 >0.1 population of monocytes. c The mRNA levels of IL-15 / IL-15RA were assessed by quantitative real-time PCR in LPS-activated hepatic DC1s isolated from noncancerous healthy tissues of resected liver specimens obtained from patients with HCC and other liver diseases. n = 3 per group. d , e The frequency of human hepatic CD8 + T RM cells when hepatic CD8 + T cells were cocultured with LPS-treated hepatic DC1s ( d ), in the presence of IL-15 blocking antibodies (α-CD122) ( e ). f The human hepatic inflammatory monocytes were cocultured with human hepatic T RM cells at a different ratio, and the frequency of annexin V + monocytes was assessed. n = 4 per group. Unpaired two-tailed Student’s t -test in a and b , multiple unpaired t -test in c and ordinary one-way ANOVA with Dunnett for the posttest f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05.

    Journal: Experimental & Molecular Medicine

    Article Title: Discovery of intrahepatic CD103 + cDC1/CD8 + T RM protective immune axis against acetaminophen-induced acute liver injury

    doi: 10.1038/s12276-025-01565-3

    Figure Lengend Snippet: a Based on the public single-cell RNA sequencing dataset from liver tissues of healthy donors and patients with APAP-ALI ( GSE223581 ), the relative expression levels of IL-15 were assessed between APAP patients and healthy donors, and the correlation between IL-15 level and CD69 + T RM population among the CD8 + T cells was evaluated. b Using the same dataset, the frequency of CD14⁺ monocytes among total liver immune cells (left) and the populaton of FCGR3A⁺ inflammatory monocytes among the CD14 + monocytes in the liver (right) were assessed between healthy donors and patients with APAP-ALI. For inflammatory monocytes, the ratio of FCGR3A >0.1 was assessed in the CD14 >0.1 population of monocytes. c The mRNA levels of IL-15 / IL-15RA were assessed by quantitative real-time PCR in LPS-activated hepatic DC1s isolated from noncancerous healthy tissues of resected liver specimens obtained from patients with HCC and other liver diseases. n = 3 per group. d , e The frequency of human hepatic CD8 + T RM cells when hepatic CD8 + T cells were cocultured with LPS-treated hepatic DC1s ( d ), in the presence of IL-15 blocking antibodies (α-CD122) ( e ). f The human hepatic inflammatory monocytes were cocultured with human hepatic T RM cells at a different ratio, and the frequency of annexin V + monocytes was assessed. n = 4 per group. Unpaired two-tailed Student’s t -test in a and b , multiple unpaired t -test in c and ordinary one-way ANOVA with Dunnett for the posttest f were used to measure significance. The error bars indicate mean ± s.e.m. ns, not significant. * P < 0.05.

    Article Snippet: For IL-12, IL-15, IL-18 and CCL2 neutralizing, mice were i.p. injected with 200 μg per mouse of anti-IL-12 antibody (clone R1-5D9), anti-CD122 (IL-15Rβ) antibody (clone TM-Beta1), anti-IL-18 antibody (clone YIGIF74-1G7) and anti-CCL2 antibody (clone 2H5) (all from BioXCell).

    Techniques: RNA Sequencing, Expressing, Real-time Polymerase Chain Reaction, Isolation, Blocking Assay, Two Tailed Test